Algorithms for Biological Dose Optimization in Ion Beam Radiotherapy
نویسندگان
چکیده
From 1997 until 2008 about 440 cancer patients were successfully treated in the ion therapy project at GSI. The patient treatment planning was performed with the software TRiP [1, 2]. A crucial part of the treatment planning is the particle number optimization with the goal to achieve a target dose distribution as close as possible to the prescribed biological dose distribution. The optimization task can be mathematically expressed by the minimization of an objective function. In this report we examine modifications of the numerical methods, used to handle the optimization problem, which we discussed in [3] and [4].
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